@docintegrative COVID-19 Treatments? Please don’t call your doctor for any! ##medical ##COVID19 ##shelterinplace ##bayarea ##docintegrative
♬ Sum 2 Prove – Lil Baby
Hello all, here is a timely review of COVID-19 treatments currently being investigated. Everything is still under investigation, but we have reason to be hopeful!
- Hydroxychloroquine (study underway in South Korea)
- Traditionally used for malaria prophylaxis, rheumatoid arthritis, lupus, porphyria
- Shows in-vitro action against coronaviruses (including SARS-CoV-2)
- Preliminary evidence from France: https://integrated.doctor/evidence-of-hydroxychloroquine-and-azithromycin-quick-breakdown/
- Heart problems as possible side effect (arrhythmias, etc.)
- Lopinavir/ritonavir (studied in China)
- Did not show evidence of treatment of pneumonia in a study in China (https://www.nejm.org/doi/full/10.1056/NEJMoa2001282)
- Further study underway in South Korea
- Remdesivir (study underway in USA, including Stanford)
- Intravenous broad spectrum antiviral with in-vitro activity against SARS-CoV-2 (used on compassionate basis)
- Also currently in clinical trial for Ebola infections
- Methylprednisolone (ongoing study in China)
- Decreased risk of death in patients exhibiting severe lung complications (ARDS)*
- Monoclonal antibodies
- May mitigate effects of cytokine storm observed in some patients
- Tocilizumab (study underway in Italy), Sarilumab (study underway in New York)
https://clinicaltrials.gov/ct2/home
https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html
https://emedicine.medscape.com/article/2500114-treatment
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020 Mar 13.
